Inhibition of Betaine‐Homocysteine Methyltransferase (BHMT) increases plasma total homocysteine (tHcy) in mice
نویسندگان
چکیده
منابع مشابه
Normal Range of Total Plasma Homocysteine Concentrations in Southern Iran
The distribution of total plasma homocysteine concentrations in relation to the sex and age is described, in a population of Shiraz, South West of Iran and compared to those reported in other populations. Two hundred and one healthy males and 201 healthy females aged >15 y were randomly selected. Total Plasma homocysteine concentrations were measured using high performance liquid chromatograp...
متن کاملEvolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes
Betaine-homocysteine S-methyltransferase (BHMT) and BHMT2 convert homocysteine to methionine using betaine and S-methylmethionine, respectively, as methyl donor substrates. Increased levels of homocysteine in blood are associated with cardiovascular disease. Given their role in human health and nutrition, we identified BHMT and BHMT2 genes and proteins from 38 species of deuterostomes including...
متن کاملBetaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans.
Elevated homocysteine levels have been associated with arteriosclerosis and thrombosis. Hyperhomocysteinemia is caused by altered functioning of enzymes of its metabolism due to either inherited or acquired factors. Betaine-homocysteine methyltransferase (BHMT) serves, next to methionine synthase, as a facilitator of methyl group donation for remethylation of homocysteine into methionine, and r...
متن کاملnormal range of total plasma homocysteine concentrations in southern iran
the distribution of total plasma homocysteine concentrations in relation to the sex and age is described, in a population of shiraz, south west of iran and compared to those reported in other populations. two hundred and one healthy males and 201 healthy females aged >15 y were randomly selected. total plasma homocysteine concentrations were measured using high performance liquid chromatograp...
متن کاملPlasma Total Homocysteine Levels in Diabetic Retinopathy
We read with great interest the recently published article by Malaguarnera et al. [1].This studywas aimed at evaluating the plasma total homocysteine (tHcy) levels in diabetic patients with and without retinopathy for the progression of diabetic retinopathy. In conclusion, higher plasma levels of tHcy have been found in diabetic patients with proliferative diabetic retinopathy compared to both ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a609-d